Key result
Regulators of G protein signaling (RGS) proteins, particularly within the B/R4 family, contribute to the pathogenesis of cardiovascular disorders of pregnancy such as preeclampsia.
This review highlights the emerging role of RGS proteins in the pathogenesis of cardiovascular dysfunctions during pregnancy, such as preeclampsia.
No immediate clinical implications for preeclampsia; leaves open RGS proteins as targets for mechanistic and interventional studies.
G protein-coupled receptor signaling mechanisms are implicated in many aspects of cardiovascular control, and dysfunction of such signaling mechanisms is commonly associated with disease states. Investigators have identified a large number of regulator of G protein signaling (RGS) proteins that variously contribute to the modulation of intracellular second-messenger signaling kinetics. These many RGS proteins each interact with a specific set of second-messenger cascades and receptor types and exhibit tissue-specific expression patterns. Increasing evidence supports the contribution of RGS proteins, or their loss, in the pathogenesis of cardiovascular dysfunctions. This review summarizes the current understanding of the functional contributions of RGS proteins, particularly within the B/R4 family, in cardiovascular disorders of pregnancy including gestational hypertension, uterine artery dysfunction, and preeclampsia.
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Perschbacher et al. (2018) conducted a review in Cardiovascular disorders of pregnancy (gestational hypertension, uterine artery dysfunction, preeclampsia). Regulators of G protein signaling (RGS) proteins was evaluated. Regulators of G protein signaling (RGS) proteins, particularly within the B/R4 family, contribute to the pathogenesis of cardiovascular disorders of pregnancy such as preeclampsia.
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