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January 1, 2023Therapeutic Advances in Cardiovascular DiseaseOpen Access

The therapeutic potential of targeting cardiac RGS4

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Why the study?

Perturbations in G protein signaling activation and termination underlie numerous heart pathologies, highlighting the need to summarize the roles of cardiac RGS proteins and their therapeutic implications.

Design

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Authors

GCGiselle Del CalvoTLTeresa Baggio LopezALAnastasios Lymperopoulos

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Overview

RGS4 upregulation highlights a candidate drug target in HF and AF; leaves open clinical translation pending targeted agents and trials.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Calvo et al. (2023) studied this question.

synapsesocial.com/papers/6a1ce427f1b3da30e489c404https://doi.org/10.1177/17539447231199350
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RGS6, a Modulator of Parasympathetic Activation in Heart2010 · 127 citations
  2. 2Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling2022 · 37 citations
  3. 3Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling2015 · 32 citations
  4. 4GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins2000 · 1,167 citations
  5. 5Pristimerin Inhibits Breast Cancer Cell Migration by Up-regulating Regulator of G Protein Signaling 4 Expression2012 · 37 citations