What does this research mean for the field?

Cardiac RGS proteins, particularly RGS4, play crucial roles in the pathophysiology of heart failure and atrial fibrillation and represent viable therapeutic targets. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 24, 2023International Journal of Molecular SciencesOpen Access

Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4

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Why the study?

This review summarizes the functional roles of cardiac RGS proteins and their implications for treating HF and AFib, focusing on RGS4 as a therapeutic target.

Design

Review

Authors

JBJordana I. BorgesNova Southeastern University MSMalka S. SusterNova Southeastern University ALAnastasios LymperopoulosHeart Failure & Transplant

Discussion

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Implication

Hypothesis-generating for RGS4-targeted therapies in heart failure; leaves open clinical efficacy in atrial fibrillation.

Structured PICO

Population

Patients with heart failure (HF) and atrial fibrillation (AFib), as well as preclinical animal and cell models of cardiac hypertrophy and failure.

Intervention

Modulation of cardiac regulator of G protein signaling (RGS) proteins, with a specific focus on RGS4.

RGS4 is upregulated in human heart failure and may serve as a compensatory, cardioprotective mechanism by terminating maladaptive Gq and Gi/o protein signaling, highlighting its potential as a therapeutic target.

Cite This Study

Borges et al. (2023) studied this question.

synapsesocial.com/papers/6a1ce427f1b3da30e489c403 https://doi.org/10.3390/ijms24076136

Topics

HFrEF treatment Heart failure Atrial fibrillation Persistent AF management

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Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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