Key result
Rgs5-null mice exhibited a significantly higher incidence of atrial tachyarrhythmia during programmed electrical stimulation compared to wild-type mice (46.7% vs 7.1%, P<0.05).
Why the study?
Does Rgs5 knockout increase susceptibility to atrial tachyarrhythmia in mice?
Population
Rgs5-null (Rgs5-/-) mice and wild-type (WT) mice (n=15 Rgs5-/-, n=14 WT)
Comparison
Rgs5 gene knockout (Rgs5-/-) vs Wild-type (WT) mice
Design
Preclinical
Authors
Loading...
Rgs5 deletion heightens atrial tachyarrhythmia susceptibility in mice; hypothesis-generating for human AF mechanisms, requires validation.
Does Rgs5 knockout increase susceptibility to atrial tachyarrhythmia in mice?
Absolute Event Rate: 46.7% vs 7.1%
p-value: p=<0.05
Rgs5 knockout in mice increases susceptibility to atrial tachyarrhythmias by prolonging atrial repolarization and decreasing repolarizing potassium currents.
Qin et al. (2012) studied Atrial tachyarrhythmia (n=29). Rgs5 knockout vs. Wild-type mice was evaluated on Incidence of atrial tachyarrhythmia during programmed electrical stimulation (p=<0.05). Rgs5-null mice exhibited a significantly higher incidence of atrial tachyarrhythmia during programmed electrical stimulation compared to wild-type mice (46.7% vs 7.1%, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: