December 6, 2013Journal of Biological ChemistryOpen Access

RGS6, but Not RGS4, Is the Dominant Regulator of G Protein Signaling (RGS) Modulator of the Parasympathetic Regulation of Mouse Heart Rate

View Full Paper

Ask AI

Bookmark

Population

Rgs4(-/-), Rgs6(-/-), Rgs4(-/-):Rgs6(-/-), and Gβ5(-/-) mice

Comparison

Genetic ablation of RGS4, RGS6, or both vs Comparison between different knockout models

Design

Preclinical

Authors

NWNicole WydevenUniversity of Minnesota EPEkaterina PosokhovaScripps Research Institute ZXZhilian XiaSt. Jude Children's Research Hospital

Discussion

Member takes

Implication

RGS6 may represent a selective target for parasympathetic HR modulation; hypothesis-generating in mice and requires human validation before clinical consideration.

Structured PICO

Population

Rgs4(-/-), Rgs6(-/-), Rgs4(-/-):Rgs6(-/-), and Gβ5(-/-) mice

Intervention

Genetic ablation of RGS4, RGS6, or both

Comparator

Comparison between different knockout models

Outcome

Parasympathetic regulation of heart rate (resting HR, heart rate variability, sensitivity to carbachol) and M2R-IKACh-dependent signaling in the sinoatrial nodesurrogate

RGS6-Gβ5, rather than RGS4, is the dominant regulator of parasympathetic heart rate regulation and sinoatrial node M2R-IKACh signaling in mice.

Cite This Study

Wydeven et al. (2013) studied this question.

synapsesocial.com/papers/6a82903c8aa2f088808d5b0e https://doi.org/10.1074/jbc.m113.520742

View Full Paper

Ask AI

Bookmark

Implication

RGS6 may represent a selective target for parasympathetic HR modulation; hypothesis-generating in mice and requires human validation before clinical consideration.

RGS6, but Not RGS4, Is the Dominant Regulator of G Protein Signaling (RGS) Modulator of the Parasympathetic Regulation of Mouse Heart Rate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

RGS6, but Not RGS4, Is the Dominant Regulator of G Protein Signaling (RGS) Modulator of the Parasympathetic Regulation of Mouse Heart Rate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider