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January 1, 2012Frontiers in PhysiologyOpen Access

Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node

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Population

RGS4-knockout mice and pacemaker cells of the sinoatrial node (SAN)

Design

Review

Authors

AMAlexandra MighiuUniversity of OxfordSHScott P. HeximerUniversity of Toronto

Discussion

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Implication

RGS4 loss may heighten bradyarrhythmia susceptibility in mice; leaves open its relevance to human sinus node dysfunction or AF.

Structured PICO

P
Population
RGS4-knockout mice and pacemaker cells of the sinoatrial node (SAN)
I
Intervention
Loss of RGS4 function (RGS4 knockout)
O
Outcome
Basal heart rate and chronotropic responses to parasympathetic agonistssurrogate

RGS4 functions as a key regulator of parasympathetic signaling in the sinoatrial node, and its loss may increase susceptibility to bradyarrhythmias and atrial fibrillation.

Cite This Study

Mighiu et al. (2012) studied this question.

synapsesocial.com/papers/6a8290720f52607ca18ad8eehttps://doi.org/10.3389/fphys.2012.00204
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Cardiac Sodium Channel Mutation Cosegregates With a Rare Connexin40 Genotype in Familial Atrial Standstill2003 · 279 citations
  2. 2RGS6/Gβ5 Complex Accelerates I KACh Gating Kinetics in Atrial Myocytes and Modulates Parasympathetic Regulation of Heart Rate2010 · 101 citations
  3. 3Ca2+Elevation Evoked by Membrane Depolarization Regulates G Protein Cycle via RGS Proteins in the Heart2001 · 43 citations
  4. 4Cardiac myocytes express mRNA for ten RGS proteins: changes in RGS mRNA expression in ventricular myocytes and cultured atria1998 · 74 citations
  5. 5Functional Characterization of a Trafficking-defective HCN4 Mutation, D553N, Associated with Cardiac Arrhythmia2004 · 229 citations