November 6, 1998FEBS LettersOpen Access

Cardiac myocytes express mRNA for ten RGS proteins: changes in RGS mRNA expression in ventricular myocytes and cultured atria

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Population

Rat cardiac myocytes (ventricular myocytes and cultured atrial pieces)

Design

Preclinical

Authors

Discussion

RGS changes in isolated myocytes suggest novel GPCR modulation; hypothesis-generating in rats, with uncertain in vivo or human relevance.

Population

Rat cardiac myocytes (ventricular myocytes and cultured atrial pieces)

Intervention

Isolation of ventricular myocytes (60-90 min) and culture of atrial pieces in medium with Ca2+ (90 min)

Outcome

Changes in RGS mRNA expression (specifically RGS-r and RGS5)surrogate

Rapid regulation of RGS levels may represent a novel mechanism governing signal transmission across the cardiac cell membrane.

Kardestuncer et al. (1998) studied this question.

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