Population
Intact cardiac cells (in situ model for muscarinic K+ channel evaluation)
Comparison
Membrane depolarization evoking intracellular… vs Prevention of intracellular Ca2+ increase
Design
Preclinical
Authors
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Highlights potential Ca2+ regulation of cardiac vagal signaling; leaves open translation to human arrhythmias or therapy.
Demonstrates a novel pathway where Ca2+-dependent signaling regulates the G protein cycle via RGS proteins in the heart.
Ishii et al. (2001) studied this question.
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