Population
Xenopus oocytes expressing various combinations of membrane receptors, G proteins, Kir3.0 subunits, and…
Design
Preclinical
Authors
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Offers mechanistic insight into K(G) channel regulation in animals; leaves open translation to human cardiac electrophysiology or therapy.
The study demonstrates that the RGS domain of RGS4 interacting with PTX-sensitive Gα subunits is essential for the voltage-dependent relaxation of G protein-gated potassium channels.
Inanobe et al. (2001) studied this question.
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