A regulator of G protein signalling (RGS) protein confers agonist‐dependent relaxation gating to a G protein‐gated K+ channel

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Population

Xenopus oocytes (heterologous expression system) and native cardiac G protein-gated K+ (KG) channels

Comparison

Co-expression of RGS4 and application of… vs Absence of RGS4

Design

Preclinical

Authors

Discussion

Hypothesis-generating for RGS4 regulation of cardiac K+ channels; leaves open translation to human physiology or therapy.

Population

Xenopus oocytes (heterologous expression system) and native cardiac G protein-gated K+ (KG) channels

Intervention

Co-expression of RGS4 and application of acetylcholine (ACh)

Comparator

Absence of RGS4

Outcome

Voltage-dependent relaxation kinetics of G protein-gated K+ (KG) channelssurrogate

RGS4 regulates G protein-gated K+ channel gating, suggesting a novel physiological target of RGS protein-mediated regulation in cardiac cells.

Fujita et al. (2000) studied this question.

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