Key result
Inhibitory G proteins and regulators of G protein signaling play a critical role in autonomic heart rate control, and their dysregulation may predispose to atrial and ventricular arrhythmias.
This review discusses the role of inhibitory G proteins and regulators of G protein signaling in heart rate control and arrhythmia predisposition using mouse models.
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Hypothesis-generating for G protein-targeted arrhythmia therapies; leaves open translation to human risk stratification or treatment.
Ang et al. (2012) conducted a review in Cardiac arrhythmias and heart rate regulation. Inhibitory G proteins and regulators of G protein signaling was evaluated. Inhibitory G proteins and regulators of G protein signaling play a critical role in autonomic heart rate control, and their dysregulation may predispose to atrial and ventricular arrhythmias.
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