January 20, 2005AJP Regulatory Integrative and Comparative Physiology

Autonomic nervous system and blood pressure regulation in RGS2-deficient mice

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Population

RGS2-deficient mice (RGS2-/-) and wild-type controls (RGS2+/+)

Comparison

RGS2 deletion and pharmacological testing vs Wild-type mice (RGS2+/+)

Design

Preclinical

Authors

VGVolkmar GroßMax Delbrück Center JTJens TankGeneral Cardiology MOMichael ObstUniversity of Fukui

Discussion

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Implication

Supports CNS sympathetic role for RGS2 in BP control; hypothesis-generating and leaves open human translation.

Structured PICO

Population

RGS2-deficient mice (RGS2-/-) and wild-type controls (RGS2+/+)

Intervention

RGS2 deletion (genetic model) and pharmacological testing (atropine, prazosin, metoprolol)

Comparator

Wild-type mice (RGS2+/+)

Outcome

Arterial blood pressure and heart rate (HR) measured with telemetrysurrogate

RGS2 deletion in mice increases blood pressure likely through a central nervous system mechanism involving increased sympathetic tone, rather than solely peripheral vascular mechanisms.

Cite This Study

Groß et al. (2005) studied this question.

synapsesocial.com/papers/6a6f3f306c240de38cdb6d18 https://doi.org/10.1152/ajpregu.00246.2004

View Full Paper

Ask AI

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Autonomic nervous system and blood pressure regulation in RGS2-deficient mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Autonomic nervous system and blood pressure regulation in RGS2-deficient mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider