What question did this study set out to answer?

To compare endothelium-dependent relaxation of isolated pulmonary arteries between patients with Eisenmenger's syndrome and control patients.

January 1, 1990British Journal of PharmacologyOpen Access

Impairment of pulmonary endothelium‐dependent relaxation in patients with Eisenmenger's syndrome

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Why the study?

Is endothelium-dependent relaxation of pulmonary arteries impaired in patients with Eisenmenger's syndrome?

Key Points

To compare endothelium-dependent relaxation of isolated pulmonary arteries between patients with Eisenmenger's syndrome and control patients.
Obtained pulmonary artery rings immediately after heart-lung transplantation from patients with Eisenmenger's syndrome (N=4) and after lobectomy from lung carcinoma controls (N=4).
Assessed dose-dependent vascular relaxation to cumulative concentrations of acetylcholine (10⁻¹⁰ to 10⁻⁵ M) following phenylephrine precontraction, and tested endothelium-independent relaxation using sodium nitroprusside (10⁻⁴ M).
Pulmonary artery rings from controls reached a maximal acetylcholine-induced relaxation of 80 ± 5%, compared with 34 ± 12% in rings from patients with Eisenmenger's syndrome (P < 0.05).
High acetylcholine concentrations (10⁻⁶ to 10⁻⁵ M) caused paradoxical vasoconstriction in pulmonary artery rings from patients with Eisenmenger's syndrome.
Sodium nitroprusside (10⁻⁴ M) completely relaxed pulmonary artery rings with and without endothelium in both control and Eisenmenger's syndrome groups.

Structured PICO

Is endothelium-dependent relaxation of pulmonary arteries impaired in patients with Eisenmenger's syndrome?

Population

n=8 total; 4 patients with Eisenmenger's syndrome and secondary pulmonary hypertension (pulmonary artery tissue obtained at heart-lung transplantation) and 4 control patients with lung carcinoma (pulmonary artery tissue obtained at lobectomy).

Intervention

Ex vivo exposure of pulmonary artery rings to cumulative doses of acetylcholine (10(-10) to 10(-5) M) and sodium nitroprusside (10(-4) M).

Comparator

Pulmonary artery rings from control patients with lung carcinoma.

Outcome

Maximal relaxation of pulmonary artery rings from precontraction with phenylephrine.surrogate

Endothelium-dependent relaxation of pulmonary arteries is significantly impaired in patients with Eisenmenger's syndrome and secondary pulmonary hypertension.

Discussion

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Implication

Impaired endothelium-dependent relaxation supports endothelial dysfunction in Eisenmenger syndrome; hypothesis-generating for targeted therapies, needs prospective validation.

Cite This Study

Dinh‐Xuan et al. (1990) studied this question.

synapsesocial.com/papers/6a6f3f33e71d69abee07ecee https://doi.org/10.1111/j.1476-5381.1990.tb14643.x

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Implication

Impaired endothelium-dependent relaxation supports endothelial dysfunction in Eisenmenger syndrome; hypothesis-generating for targeted therapies, needs prospective validation.

Impairment of pulmonary endothelium‐dependent relaxation in patients with Eisenmenger's syndrome

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Impairment of pulmonary endothelium‐dependent relaxation in patients with Eisenmenger's syndrome

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider