Demonstrates that a 26 kDa peptide from skeletal myosin S1 heavy chain can interact with actin in an ATP-sensitive manner.
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No immediate clinical relevance; extends myosin fragment biochemistry while leaving in vivo contractile roles open.
A 26 kDa peptide has been cleaved from the C-terminus of the S1 heavy chain with formic acid. Cleavage occurs in the '50 kDa' domain probably at the Asp-600-Pro-601 bond. This fragment has been renatured in the presence of the A2 light chain and the 26 kDa(A2) complex shown to interact with actin in an ATP-sensitive manner.
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Griffiths et al. (1989) studied this question.
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