March 27, 1989FEBS LettersOpen Access

Selective cleavage at lysine of the 50 kDa‐20 kDa connector loop segment of skeletal myosin S‐1 by endoproteinase Arg‐C

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Population

Skeletal myosin head heavy chain (S-1)

Design

Preclinical

Authors

Discussion

Arg-C offers a selective probe for skeletal myosin conformation; leaves open extension to cardiac isoforms or in vivo relevance.

Population

Skeletal myosin head heavy chain (S-1)

Intervention

Endoproteinase Arg-C

Outcome

Cleavage site and specificity on the myosin heavy chain

Endoproteinase Arg-C acts as a highly specific conformational probe for skeletal myosin S-1 by exclusively cleaving the 50 kDa-20 kDa junction.

Bertrand et al. (1989) studied this question.

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