September 25, 1984Biochemistry

Nucleotide-induced changes in the proteolytically sensitive regions of myosin subfragment 1

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Population

Myosin subfragment 1 (S-1)

Design

Preclinical

Authors

Discussion

Nucleotide effects on myosin S1 cleavage remain preclinical; leaves open relevance to cardiac contractility or therapies pending human validation.

Population

Myosin subfragment 1 (S-1)

Intervention

Nucleotides (2 mM MgADP and 5 mM MgATP)

Outcome

Rate and sites of proteolytic cleavage by elastase, subtilisin, papain, and thermolysinsurrogate

Nucleotide binding at the active site of myosin subfragment 1 induces conformational changes that alter its susceptibility to proteolytic cleavage.

Applegate et al. (1984) studied this question.

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Nucleotide effects on myosin S1 cleavage remain preclinical; leaves open relevance to cardiac contractility or therapies pending human validation.