Key result
Female sex was associated with a significantly lower incidence of stroke compared to male sex among hypertensive patients (HR 0.44), with about 25% of the disparity explained by traditional risk factors.
Why the study?
Few studies had investigated sex differences in stroke incidence among the hypertensive population in rural China.
Cohort (n=5,097)
Yes
Hazard Ratio: 0.44 (95% CI 0.35–0.55)
Absolute Event Rate: 920.8% vs 1652.51%
In a rural Chinese hypertensive cohort, men had a significantly higher incidence of stroke than women, with approximately 25% of this difference explained by traditional cardiovascular risk factors.
Should not yet change hypertension management; hypothesis-generating for unmeasured factors in residual sex disparity.
BACKGROUND: Few studies investigate sex difference in stroke incidence in rural China hypertensive population. METHODS: A total of 5097 hypertensive patients aged ≥35 years (mean age, 56.3 ± 11.2 years; 43.8% men) were included in our analysis with a median follow-up 8.4 years in Fuxin county of Liaoning province in China. Cox proportional hazard models were used to analyze the association between the potential factors and incident stroke. RESULTS: We observed 501 new strokes (310 ischemic, 186 hemorrhagic, and 5 unclassified stroke) during the follow-up. The overall incidence of stroke was 1235.21 per 100,000 person-years; for men, the rates were 1652.51 and 920.80 for women. This sex difference in all stroke can be explained by approximately 25% through age, systolic blood pressure, body mass index, low-density lipoprotein-cholesterol, current smoking, current drinking, antihypertensive drugs, education and physical activity. Subgroup analysis indicated that in hemorrhagic stroke this sex difference was more remarkable (63.89% can be explained). CONCLUSIONS: The incidence of stroke was higher in men than that in women and this difference was partly explained by several traditional cardiovascular risk factors.
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Wang et al. (2019) conducted a cohort in Hypertension (n=5,097). Female sex vs. Male sex was evaluated on Incident stroke (HR 0.44, 95% CI 0.35-0.55). Female sex was associated with a significantly lower incidence of stroke compared to male sex among hypertensive patients (HR 0.44), with about 25% of the disparity explained by traditional risk factors.
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