Griseofulvin [7chloro -4:6:2' -trimethoxy -6'- methylgris-2'-en-3:4'-dione (I:R, R', Me)], a pro- duct of Penicillium gri8eofulvum Dierckx, was first isolated by Oxford, Raistrick & Simonart (1939): its structure was first established by Grove, Ismay, MacMillan, Mulholland & Rogers (1951). This compound has fungistatic activity and was reported to control experimental ringworm in guinea pigs (Gentles, 1958) and in calves (Lauder & O'Sullivan, 1958) when administered orally.
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Barnes et al. (1961) studied this question.