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April 1, 1970British Journal of PharmacologyOpen Access

Regional circulatory effects of pancreatic glucagon

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Why the study?

Does intra-arterial glucagon alter regional blood flow in anaesthetized cats?

Population

Anaesthetized cats

Design

Preclinical

Authors

GRG. T. ROSSThe Francis Crick Institute

Discussion

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Implication

Glucagon's splanchnic-selective effects in cats leave open receptor mechanisms and human translation; hypothesis-generating only.

Structured PICO

Does intra-arterial glucagon alter regional blood flow in anaesthetized cats?

P
Population
Anaesthetized cats
I
Intervention
Close intra-arterial injections and infusions of glucagon (threshold dose <1 mug, maximal 10-20 mug)
O
Outcome
Blood flow in the femoral, hepatic and superior mesenteric arteries measured using non-cannulating electromagnetic flow probessurrogate

Glucagon is a potent vasoactive substance with effects predominantly confined to the splanchnic area, and its vasodilatory effects may not be mediated via beta-adrenoceptors.

Cite This Study

G. T. ROSS (1970) studied this question.

synapsesocial.com/papers/6a6f46676ceb2bbd16dfa3b5https://doi.org/10.1111/j.1476-5381.1970.tb09882.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic Effects of Glucagon in Patients with Heart Disease1969 · 105 citations
  2. 2SELECTIVE BLOCKADE OF ADRENOCEPTIVE BETA RECEPTORS IN THE HEART1968 · 416 citations
  3. 3Use of Liver Adenyl Cyclase for Assay of Glucagon in Human Gastro-intestinal Tract and Pancreas11964 · 148 citations
  4. 4DIMETHYL ISOPROPYLMETHOXAMINE: A SELECTIVE β‐RECEPTOR BLOCKING AGENT1966 · 23 citations
  5. 5Glucagon1968 · 248 citations