What question did this study set out to answer?

This research aims to evaluate the hemodynamic effects of glucagon in patients with heart disease.

January 1, 1969CirculationOpen Access

Hemodynamic Effects of Glucagon in Patients with Heart Disease

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Why the study?

Does intravenous glucagon improve hemodynamic parameters in patients with heart disease?

Population

13 patients with heart disease

Comparison

Glucagon 3 or 5 mg intravenous vs Baseline values; 8 patients also received…

Design

Case_series

Follow-up

15 minutes

Authors

JWJohn F. WilliamsUniversity of Florida RCRICHARD H. CHILDRESSSprint (United States)JCJerold N. ChipIndiana University Hospital

Discussion

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Implication

May support short-term inotropic use in heart disease; hypothesis-generating and requires randomized confirmation before practice change.

Key Points

This research aims to evaluate the hemodynamic effects of glucagon in patients with heart disease.
Intravenous glucagon administered at doses of 3 or 5 mg to 13 heart disease patients.
Hemodynamic parameters measured post-administration, including heart rate and cardiac index.
Comparison of glucagon effects with isoproterenol infusion in eight patients.
Average increase in cardiac index of 19%, with nine patients showing over 10% increase from baseline.
Significant heart rate and left ventricular pressure increases noted, with a decline in systemic vascular resistance.
Glucagon effects peaked within 15 minutes and lasted a short duration, with some patients displaying varying responses.

Structured PICO

Does intravenous glucagon improve hemodynamic parameters in patients with heart disease?

Population

13 patients with heart disease

Intervention

Glucagon 3 or 5 mg intravenous

Comparator

Baseline values; 8 patients also received isoproterenol infusion for comparison

Outcome

Hemodynamic changes (heart rate, cardiac index, stroke power index, mean rate of left ventricular ejection, maximum rate of rise of left ventricular pressure, systemic vascular resistance) reaching maximum within 15 minutessurrogate

Intravenous glucagon produces short-acting positive inotropic and chronotropic effects without significant arrhythmias in patients with heart disease.

Cite This Study

Williams et al. (1969) studied this question.

synapsesocial.com/papers/6a6f46ef78a11c550e08f5e2 https://doi.org/10.1161/01.cir.39.1.38

Topics

Cardiomyopathy Hypertension management

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Hemodynamic Effects of Glucagon in Patients with Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Hemodynamic Effects of Glucagon in Patients with Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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