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June 1, 1980Annual Review of Biochemistry

Transglutaminases

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Authors

JFJ.E. FolkNational Institute on Drug Abuse

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Overview

Review reveals Hippo signaling controls organ size and cell fate across species, highlighting conserved mechanisms.

Key Points

  • To examine the evolutionary conservation of the Hippo signaling cascade and its biological role in regulating organ size, tissue growth, and cell fate decisions.
  • Literature synthesis of genetic and biochemical studies starting from Drosophila melanogaster models
  • Analysis of conserved molecular components governing organ growth and cellular homeostasis
  • The Hippo signaling pathway functions as an evolutionarily conserved network critical for restricting organ size across multicellular organisms.
  • Pathway components directly control fundamental biological processes including cellular proliferation, apoptosis, and cell fate determination.

Cite This Study

J.E. Folk (1980) studied this question.

synapsesocial.com/papers/6a6f484fb27f15817826ed8dhttps://doi.org/10.1146/annurev.bi.49.070180.002505
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