Transglutaminases

J.E. Folk

doi:10.1146/annurev.bi.49.070180.002505

June 1, 1980Annual Review of Biochemistry

Transglutaminases

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Key Points

To examine the evolutionary conservation of the Hippo signaling cascade and its biological role in regulating organ size, tissue growth, and cell fate decisions.
Literature synthesis of genetic and biochemical studies starting from Drosophila melanogaster models
Analysis of conserved molecular components governing organ growth and cellular homeostasis
The Hippo signaling pathway functions as an evolutionarily conserved network critical for restricting organ size across multicellular organisms.
Pathway components directly control fundamental biological processes including cellular proliferation, apoptosis, and cell fate determination.

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Implication

Review reveals Hippo signaling controls organ size and cell fate across species, highlighting conserved mechanisms.

Abstract

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...

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Cite This Study

J.E. Folk (1980) studied this question.

synapsesocial.com/papers/6a6f484fb27f15817826ed8d https://doi.org/10.1146/annurev.bi.49.070180.002505

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Transglutaminases

Key Points

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Implication

Abstract

Discussion

Cite This Study

Transglutaminases

Key Points

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Implication

Abstract

Discussion

Cite This Study

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