Why the study?
Do rhinovirus-sensitive HeLa cells improve the isolation rate of rhinoviruses compared to human embryo lung fibroblasts in clinical specimens?
Population
517 patients with respiratory disease yielding 526 rhinovirus isolates between May 1970 and December 1974.
Comparison
Viral isolation using rhinovirus-sensitive HeLa… vs Viral isolation using human embryo lung…
Authors
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HeLa 'R' cells may boost rhinovirus isolation rates in clinical labs; leaves open relevance versus modern molecular methods.
Do rhinovirus-sensitive HeLa cells improve the isolation rate of rhinoviruses compared to human embryo lung fibroblasts in clinical specimens?
HeLa 'R' cells are significantly more sensitive than HEL cells for the routine clinical isolation of rhinoviruses, yielding higher isolation rates and infectivity titers.
Lewis et al. (1976) studied this question.
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