Key result
Rhinovirus A infection kinetics, viral protein synthesis, and subcellular localization were remarkably similar between human primary bronchial epithelial cells and HeLa cells.
Population
Human primary bronchial epithelial cells (hBE) and HeLa cells
Comparison
Rhinovirus A (A01a) infection vs Matched infections in the other cell type
Design
Preclinical
Follow-up
up to 24 hours post-infection
Authors
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HeLa cells may model rhinovirus A infection; leaves open validation in complex human systems.
HeLa cells provide a relevant model for studying the rhinovirus life cycle and its effects on cellular metabolism, as key infection processes closely resemble those in natural primary human bronchial epithelial cells.
Amineva et al. (2011) studied Rhinovirus A infection. Rhinovirus A infection in human primary bronchial epithelial cells (hBE) vs. HeLa cells was evaluated on Kinetics of RNA replication, viral protein synthesis, and subcellular localization. Rhinovirus A infection kinetics, viral protein synthesis, and subcellular localization were remarkably similar between human primary bronchial epithelial cells and HeLa cells.
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