Why the study?
What factors best predict the amount of morphine used in the first 24 h after surgery via PCA?
Population
1010 patients under 70 years old prescribed morphine via patient-controlled analgesia after major operations
Design
Cohort
Follow-up
24 hours
Authors
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Age may guide initial PCA morphine dosing; this Level 3 cohort finding leaves open prospective validation before practice change.
What factors best predict the amount of morphine used in the first 24 h after surgery via PCA?
Initial postoperative morphine doses should be guided by patient age rather than weight, using the formula 100 - age (in mg) for the first 24 hours.
Macintyre et al. (1996) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: