Key result
Hypoxia stimulated transglutaminase 2 expression and activity in pulmonary artery smooth muscle cells, leading to enhanced cell proliferation that was blocked by TG2 inhibition.
Population
Cultured distal bovine pulmonary artery smooth muscle cells and proximal human PASMCs derived from…
Comparison
Hypoxia exposure for up to 24 hours, with or… vs Normoxia exposure and/or vehicle/mock…
Design
Preclinical
Follow-up
24 hours
Authors
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TG2 inhibition blocks hypoxia-driven PASMC proliferation; hypothesis-generating for targeting vascular remodeling in pulmonary hypertension.
Hypoxia-induced proliferation of pulmonary artery smooth muscle cells is mediated by transglutaminase 2, highlighting its potential as a therapeutic target for vascular remodeling in pulmonary hypertension.
Penumatsa et al. (2014) studied Pulmonary hypertension. Hypoxia (3% O2) vs. Normoxia (21% O2) was evaluated on Cell proliferation and TG2 activity/expression. Hypoxia stimulated transglutaminase 2 expression and activity in pulmonary artery smooth muscle cells, leading to enhanced cell proliferation that was blocked by TG2 inhibition.
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