Why the study?
Does TG2 inhibition reduce hypoxia-induced tissue matrix remodeling in experimental pulmonary hypertension?
Population
Mouse model of experimental pulmonary hypertension and cultured primary human cardiac and pulmonary artery…
Comparison
Pharmacological inhibition of TG2 activity with… vs Hypoxia exposure without TG2 inhibition
Design
Preclinical
Authors
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TG2 inhibition may limit PH fibrosis in models; leaves open clinical translation.
Does TG2 inhibition reduce hypoxia-induced tissue matrix remodeling in experimental pulmonary hypertension?
Inhibition of transglutaminase 2 reduces hypoxia-induced pulmonary and right ventricular tissue matrix remodeling in experimental pulmonary hypertension.
Penumatsa et al. (2017) studied this question.
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