Population
Superior cervical ganglion neurons from myosin IIB knock-out mice and wild-type littermates
Comparison
Myosin IIB knock-out vs Wild-type (WT) neurons from normal littermates
Design
Preclinical
Authors
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Myosin IIB supports growth cone traction; leaves open other myosins' roles and mammalian validation.
Myosin IIB is required for normal growth cone spreading and traction force generation, though other myosins also contribute to filopodial-dependent traction.
Bridgman et al. (2001) studied this question.
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