Why the study?
Does myosin IIB knockout alter retrograde flow rate in growth cones?
Population
Growth cones from myosin-IIB-knockout mice and normal littermates
Comparison
Myosin IIB knockout vs Wild-type (normal littermates)
Design
Preclinical
Authors
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Suggests distinct myosin II isoform roles in growth cone advance; hypothesis-generating for neuronal motility in vivo.
Does myosin IIB knockout alter retrograde flow rate in growth cones?
Myosin IIB knockout leads to a more than two-fold increase in retrograde flow rate in growth cones, suggesting myosin II isoforms play distinct roles in forward advance.
Brown et al. (2003) studied this question.
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