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October 21, 2021Preventive MedicineOpen Access

Life's Simple 7 and the risk of stroke in Finnish men: A prospective cohort study

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Key result

A high Life's Simple 7 score was associated with a 48% lower risk of total stroke compared to a low score among middle-aged Finnish men (HR 0.52; 95% CI 0.32-0.86).

Why the study?

Population-wide preventive measures are important for reducing stroke burden, prompting investigation into the association between the AHA Life's Simple 7 score and stroke risk in men.

Does a higher AHA Life's Simple 7 score reduce the risk of stroke in middle-aged men?

Population

2520 men aged 42-60 years without a history of stroke in Finland

Comparison

High (5-7) vs medium (3-4) vs low (0-2) ideal LS7 metrics

Design

Prospective population-based cohort study

Follow-up

Median 26 years

Authors

NINzechukwu M. IsiozorUniversity of Eastern FinlandSKSetor K. KunutsorGeneral / Preventive / LipidsAVAri VoutilainenGeneral / Preventive / Lipids

Discussion

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Member takes

Overview

May inform stroke risk stratification in men; leaves open whether LS7-targeted interventions reduce incidence.

Study Design

Type

Cohort (n=2,520)

Structured PICO

Does a higher AHA Life's Simple 7 score reduce the risk of stroke in middle-aged men?

P
Population
2,520 Finnish men aged 42-60 years without prior stroke, followed for a median of 26 years.
E
Exposure
High (5-7 ideal metrics) or medium (3-4 ideal metrics) AHA Life's Simple 7 (LS7) score
C
Comparator
Low (0-2 ideal metrics) AHA Life's Simple 7 (LS7) score
O
Outcome
Incident total stroke and ischaemic strokehard clinical

Main Result

Hazard Ratio: 0.52 (95% CI 0.32–0.86)

Higher adherence to the AHA Life's Simple 7 cardiovascular health metrics is associated with a significantly lower long-term risk of total and ischemic stroke in middle-aged men.

Cite This Study

Isiozor et al. (2021) conducted a cohort in Stroke (n=2,520). High Life's Simple 7 (LS7) score vs. Low LS7 score was evaluated on Total stroke (HR 0.52, 95% CI 0.32-0.86). A high Life's Simple 7 score was associated with a 48% lower risk of total stroke compared to a low score among middle-aged Finnish men (HR 0.52; 95% CI 0.32-0.86).

synapsesocial.com/papers/6a6f4daf35aa2c282ce0b03ehttps://doi.org/10.1016/j.ypmed.2021.106858
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular Health and Stroke in Older British Men2020 · 24 citations
  2. 2American heart association’s cardiovascular health metrics and risk of cardiovascular disease mortality among a middle-aged male Scandinavian population2019 · 27 citations
  3. 3The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study2019 · 24 citations
  4. 4Association between ideal cardiovascular health metrics and risk of cardiovascular events or mortality: A meta‐analysis of prospective studies2017 · 165 citations
  5. 5Association Between Sauna Bathing and Fatal Cardiovascular and All-Cause Mortality Events2015 · 288 citations