Key result
A high level of Life's Essential 8 was associated with significantly lower odds of hyperuricaemia compared to a low level (OR 0.45; 95% CI 0.42-0.48; Ptrend < 0.001).
Why the study?
Life's Essential 8 is a new comprehensive metric based on Life's Simple 7, but few studies have investigated the association between LE8 and the odds of hyperuricaemia.
Do higher scores on Life's Essential 8 and Life's Simple 7 reduce the odds of hyperuricaemia in a multi-ethnic Chinese cohort?
Cross-Sectional (n=89,823)
Yes
Do higher scores on Life's Essential 8 and Life's Simple 7 reduce the odds of hyperuricaemia in a multi-ethnic Chinese cohort?
Odds Ratio: 0.45 (95% CI 0.42–0.48)
p-value: p=<0.001
Objective Life’s Essential 8 (LE8) is a new comprehensive metric based on Life’s Simple 7 (LS7). Few studies have investigated the association between LE8 and the odds of hyperuricaemia (HUA). This study examined the association between LE8, LS7 with odds of HUA. Methods We cross-sectionally analysed data from the China Multi-Ethnic Cohort (CMEC) study. LE8 and LS7 were categorized as low, moderate and high. The CMEC provided an ideal and unique opportunity to characterize the association between LE8, LS7 and the odds of HUA. Results Of the 89 823 participants, 14 562 (16.2%) had HUA. A high level of LE8 was associated with lower odds of HUA after full adjustment. The adjusted odds ratios (ORs) were 1 (reference), 0.70 (95% CI 0.67, 0.73) and 0.45 (0.42, 0.48) across low, moderate and high LE8 groups, respectively (Ptrend < 0.001). Similar results were observed in LS7 and HUA. The adjusted ORs were 1 (reference), 0.68 (95% CI 0.65, 0.71) and 0.46 (95% CI 0.43, 0.49) across low, moderate and high LS7 groups, respectively (Ptrend < 0.001). There were significant interactions between LE8 and age, gender, ethnicity and drinking habits on HUA. Receiver operating characteristics analysis showed that the area under the curve for LE8 and LS7 were similar (0.638 and 0.635, respectively). Conclusion This study indicated a clearly inverse gradient association between the cardiovascular health metrics LE8 and LS7 and the odds of HUA.
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Wang et al. (2023) conducted a cross-sectional in Hyperuricaemia (n=89,823). High level of Life's Essential 8 (LE8) vs. Low level of LE8 was evaluated on Odds of hyperuricaemia (HUA) (OR 0.45, 95% CI 0.42-0.48, p=<0.001). A high level of Life's Essential 8 was associated with significantly lower odds of hyperuricaemia compared to a low level (OR 0.45; 95% CI 0.42-0.48; Ptrend < 0.001).
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