Key result
Positivity for both R2I2 and PERS biomarkers was associated with a 21.6-fold higher relative risk of ventricular arrhythmia or sudden cardiac death in ischaemic cardiomyopathy patients (p<0.0001).
Why the study?
Do ECG-based restitution biomarkers (R2I2 and PERS) predict the risk of ventricular arrhythmia or sudden cardiac death in patients with ischaemic cardiomyopathy?
Population
60 patients with ischaemic cardiomyopathy undergoing implantable cardioverter defibrillator risk…
Design
Cohort, blinded
Follow-up
median 22 months
Authors
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May support risk stratification in ischaemic cardiomyopathy; leaves open prospective validation before clinical adoption.
Observational (n=60)
Blinded
Do ECG-based restitution biomarkers (R2I2 and PERS) predict the risk of ventricular arrhythmia or sudden cardiac death in patients with ischaemic cardiomyopathy?
Relative Risk: 21.6
p-value: p=<0.0001
The combination of R2I2 and PERS ECG biomarkers strongly predicts the risk of ventricular arrhythmias and sudden cardiac death in patients with ischemic cardiomyopathy, offering a potential tool for improved risk stratification.
Nicolson et al. (2014) conducted an observational in Ischaemic cardiomyopathy (ICM) (n=60). R2I2 and PERS positivity vs. R2I2 and PERS negativity was evaluated on Ventricular arrhythmia (VA) or sudden cardiac death (SCD) (RR 21.6, p=<0.0001). Positivity for both R2I2 and PERS biomarkers was associated with a 21.6-fold higher relative risk of ventricular arrhythmia or sudden cardiac death in ischaemic cardiomyopathy patients (p<0.0001).
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