December 16, 2006Cardiovascular Research
Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart
Why the study?
Does direct sympathetic and vagus nerve stimulation modulate electrical restitution, alternans, and ventricular fibrillation threshold in isolated rabbit hearts?
Population
Isolated rabbit hearts with intact dual autonomic innervation (n=16)
Comparison
Direct sympathetic and vagus nerve stimulation vs Baseline (no stimulation)
Design
Preclinical
Authors
Discussion
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Implication
Autonomic modulation of VF susceptibility shown in rabbits; hypothesis-generating, leaves open human translation.
Structured PICO
Does direct sympathetic and vagus nerve stimulation modulate electrical restitution, alternans, and ventricular fibrillation threshold in isolated rabbit hearts?
P
Population
Isolated rabbit hearts with intact dual autonomic innervation (n=16)
I
Intervention
Direct sympathetic (SS) and vagus (VS) nerve stimulation
C
Comparator
Baseline (no stimulation)
O
Outcome
Electrical restitution (maximum slope), effective refractory period (ERP), electrical alternans, and ventricular fibrillation threshold (VFT)surrogate
Sympathetic stimulation increases the maximum slope of electrical restitution and electrical alternans while decreasing the ventricular fibrillation threshold, whereas vagal stimulation has the opposite protective effects, highlighting the role of autonomic modulation in arrhythmogenesis.
Cite This Study
Ng et al. (2006) studied this question.