Key result
Direct vagus nerve stimulation increased ventricular fibrillation threshold and flattened the APD restitution curve in isolated rabbit hearts, effects that were blocked by NO synthase inhibition.
Why the study?
Does nitric oxide mediate the protective effect of vagus nerve stimulation on ventricular fibrillation in isolated rabbit hearts?
Population
Innervated, isolated rabbit hearts (n = 7)
Comparison
Vagus nerve stimulation in the presence of NO… vs Baseline and VNS alone (control)
Design
Preclinical
Authors
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Nitric oxide mediates vagal anti-fibrillatory effects in rabbit hearts; leaves open translation to human VF prevention.
Does nitric oxide mediate the protective effect of vagus nerve stimulation on ventricular fibrillation in isolated rabbit hearts?
Nitric oxide mediates the anti-fibrillatory effect of vagus nerve stimulation in the rabbit ventricle by flattening the action potential duration restitution curve.
Brack et al. (2007) studied Ventricular fibrillation (n=7). Vagus nerve stimulation (VNS) with NO synthase inhibition (L-NA) and L-arginine vs. Baseline was evaluated on Maximum slope of action potential duration restitution and ventricular fibrillation threshold. Direct vagus nerve stimulation increased ventricular fibrillation threshold and flattened the APD restitution curve in isolated rabbit hearts, effects that were blocked by NO synthase inhibition.
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