Key result
Vagus nerve stimulation increases ventricular nitric oxide release and fibrillation threshold via post-ganglionic efferent nerve fibres, independent of muscarinic receptor activation.
Why the study?
Does vagus nerve stimulation increase ventricular fibrillation threshold independent of muscarinic receptor activation in an isolated rabbit heart model?
Does vagus nerve stimulation increase ventricular fibrillation threshold independent of muscarinic receptor activation in an isolated rabbit heart model?
Vagal anti-fibrillatory action in the rabbit ventricle occurs via post-ganglionic efferent nerve fibres, independent of muscarinic receptor activation, VIP, and the endothelium, suggesting a novel ventricular nitrergic parasympathetic innervation.
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Vagal nitrergic anti-fibrillatory effects in rabbit models leave open translation to human VF prevention strategies.
Brack et al. (2011) studied Ventricular fibrillation. Vagus nerve stimulation vs. Control (baseline) was evaluated on Ventricular NO release and ventricular fibrillation threshold (VFT). Vagus nerve stimulation increases ventricular nitric oxide release and fibrillation threshold via post-ganglionic efferent nerve fibres, independent of muscarinic receptor activation.
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