Key result
Cervical vagus nerve stimulation in isolated rabbit hearts increased NO-dependent fluorescence in the ventricle by up to 1.91 +/- 0.27% at high frequency, which was inhibited by L-NNA and TRIM.
Population
Isolated innervated rabbit heart model
Comparison
Stimulation of the cervical vagus nerves and… vs Baseline and absence of inhibitors
Design
Preclinical
Authors
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Vagal stimulation induces ventricular NO via nNOS in rabbits; leaves open translation to human autonomic therapies.
Activation of cardiac parasympathetic efferent nerve fibres by cervical vagus stimulation causes NO production and release in the rabbit ventricle via neuronal nitric oxide synthase.
Brack et al. (2009) studied this question. Cervical vagus nerve stimulation vs. baseline / presence of L-NNA or TRIM was evaluated on NO-dependent fluorescence in the ventricle. Cervical vagus nerve stimulation in isolated rabbit hearts increased NO-dependent fluorescence in the ventricle by up to 1.91 +/- 0.27% at high frequency, which was inhibited by L-NNA and TRIM.
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