Key result
Right and left vagal nerve stimulation similarly prolong ventricular ARI, strongly correlating with decreased inotropy.
Why the study?
Does right and left vagal nerve stimulation affect ventricular electrophysiological properties and hemodynamics in a porcine model?
Does right and left vagal nerve stimulation affect ventricular electrophysiological properties and hemodynamics in a porcine model?
Right and left vagal nerve stimulation have similar effects on ventricular activation recovery intervals, with the decrease in inotropy correlating best with ventricular electrophysiological effects.
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Porcine symmetry in vagal ventricular effects is hypothesis-generating; leaves open translation to human neuromodulation.
Yamakawa et al. (2014) studied this question. Right and left vagal nerve stimulation similarly prolonged ventricular activation recovery intervals and decreased inotropy, which correlated strongly with ARI effects (R2=0.81, P<0.0001).
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