Key result
Atropine premedication during electroconvulsive therapy significantly worsened cardiac autonomic dysfunction compared to no atropine (60.9% vs 47.0%; 95% CI 6.5-21.3; P<0.001).
Why the study?
Does atropine premedication worsen cardiac autonomic dysfunction in psychiatric patients undergoing electroconvulsive therapy?
Population
41 psychiatric patients undergoing electroconvulsive therapy (ECT)
Comparison
Atropine premedication during ECT vs No atropine premedication during ECT
Design
RCT, Randomized either to receive atropine or not to receive atropine during…
Follow-up
300 seconds after ECT
Authors
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Suggests caution with atropine premedication in ECT; leaves open confirmation in randomized trials.
RCT (n=41)
crossover
Does atropine premedication worsen cardiac autonomic dysfunction in psychiatric patients undergoing electroconvulsive therapy?
Absolute Event Rate: 60.9% vs 47%
p-value: p=<0.001
Atropine premedication during ECT significantly worsens cardiac autonomic dysfunction and should be restricted to patients susceptible to bradyarrhythmia.
Jadhav et al. (2017) conducted an RCT in psychiatric illnesses (n=41). Atropine premedication vs. No atropine premedication was evaluated on Autonomic dysfunction (%) after ECT (95% CI 6.5-21.3, p=<0.001). Atropine premedication during electroconvulsive therapy significantly worsened cardiac autonomic dysfunction compared to no atropine (60.9% vs 47.0%; 95% CI 6.5-21.3; P<0.001).