Key result
Elevated neutrophil-to-albumin ratio is an independent predictor of aortic valve sclerosis (OR 3.401) and demonstrates moderate diagnostic accuracy with a sensitivity of 56% and specificity of 58%.
Why the study?
Aortic valve sclerosis primarily affects the elderly and can progress to calcific aortic valve disease, prompting evaluation of the diagnostic potential of the neutrophil-to-albumin ratio in predicting it.
Does an elevated neutrophil-to-albumin ratio predict the presence of aortic valve sclerosis in patients undergoing transthoracic echocardiography?
Observational (n=494)
No
Does an elevated neutrophil-to-albumin ratio predict the presence of aortic valve sclerosis in patients undergoing transthoracic echocardiography?
Odds Ratio: 3.401 (95% CI 1.3–8.902)
p-value: p=0.013
An elevated neutrophil-to-albumin ratio is an independent predictor of aortic valve sclerosis, suggesting its potential utility as a simple, non-invasive biomarker for early identification of patients at risk.
NAR may aid AVS identification in observational cohorts; leaves open prospective validation before any diagnostic role.
Objectives: Aortic valve sclerosis (AVS) is the thickening or calcification of the aortic valve without significant obstruction, primarily affecting the elderly and potentially progressing to calcific aortic valve disease with high morbidity and mortality.This study evaluates the diagnostic potential of the neutrophil-to-albumin ratio (NAR) in predicting AVS.Methods: In this retrospective study, 494 patients aged 18-75 who underwent transthoracic echocardiography between December 2022 and March 2024 were analyzed.Patients were divided into two groups: 401 with AVS and 93 without.NAR was calculated from laboratory data.Results: The AVS group had higher rates of diabetes mellitus, hypertension, and coronary artery disease compared to the control group (p<0.001 for all).Laboratory findings showed elevated fasting blood glucose, creatinine, cholesterol, HDL-C, LDL-C, WBC, and neutrophil counts in the AVS group.Multivariate analysis identified hypertension, diabetes mellitus, reduced left ventricular ejection fraction, and elevated NAR as independent predictors of AVS.Sensitivity of NAR in diagnosis of AVS was 56% and specificity 58%.Conclusion: Elevated NAR is significantly associated with AVS and is an independent predictor.These findings suggest NAR could be a valuable marker for early diagnosis and management of AVS.Further research is needed to explore the mechanisms and potential therapeutic interventions targeting inflammation in AVS
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Kıvrak et al. (2024) conducted an observational in Aortic valve sclerosis (n=494). Elevated neutrophil-to-albumin ratio (NAR) vs. Lower neutrophil-to-albumin ratio was evaluated on Independent prediction of aortic valve sclerosis (OR 3.401, 95% CI 1.300-8.902, p=0.013). Elevated neutrophil-to-albumin ratio is an independent predictor of aortic valve sclerosis (OR 3.401) and demonstrates moderate diagnostic accuracy with a sensitivity of 56% and specificity of 58%.
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