Key result
Black breast cancer patients initiating aromatase inhibitors had a significantly higher median ASCVD risk score (p=0.009) and more CVD risk factors (p<0.05) compared to White patients.
Cohort (n=146)
Black breast cancer patients initiating aromatase inhibitors have significantly higher ASCVD risk scores and more CVD risk factors than their White counterparts, highlighting racial disparities in cardiovascular health.
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May warrant closer CVD monitoring in Black patients starting aromatase inhibitors; leaves open need for prospective disparity trials.
The purpose of this study was to compare the cardiovascular health of Black and White breast cancer patients undergoing adjuvant treatment. Baseline data from a cohort study of Black (n = 45) and White (n = 101) breast cancer patients initiating aromatase inhibitor treatment were analyzed. Participants had a cardiovascular health assessment, including carotid intimal medial thickness measurement, donated a blood sample, and completed a questionnaire. Atherosclerotic cardiovascular disease (ASCVD) event risk scores were calculated. Compared to their White counterparts, the Black patients had a significantly higher median ASCVD risk score (p = 0.009) and had a higher number of CVD risk factors (p < 0.05). Black patients were also more likely to have hypertension, diabetes, or to be obese than the White participants. The prevalence of cardiovascular disease and cardiovascular disease risk factors among Black and White breast cancer patients is high, and racial disparities exist which may have treatment implications.
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Gallicchio et al. (2016) conducted a cohort in Breast cancer (n=146). Black race vs. White race was evaluated on Median ASCVD risk score (p=0.009). Black breast cancer patients initiating aromatase inhibitors had a significantly higher median ASCVD risk score (p=0.009) and more CVD risk factors (p<0.05) compared to White patients.
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