Key result
Cessation of physical activity via 7-day wheel lock in 70- to 77-day-old rats evoked adipocyte hyperplasia and fat mass gain without inflammation, unlike in 49- to 56-day-old rats.
Why the study?
Does the cessation of physical activity affect adipose tissue characteristics differently depending on the age of the rats?
Does the cessation of physical activity affect adipose tissue characteristics differently depending on the age of the rats?
Cessation of physical activity induces adipocyte hyperplasia and fat mass gain in older (70-77 days) but not younger (49-56 days) rats.
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Age may modulate adipose responses to inactivity in rats; leaves open translation to human sedentary behavior or guidelines.
Roberts et al. (2013) studied Physical activity cessation. Wheel lock (cessation of physical activity) vs. Continuous wheel access (RUN) was evaluated on Adipose tissue characteristics (fat mass, percent body fat, adipocyte number, cyclin A1 mRNA). Cessation of physical activity via 7-day wheel lock in 70- to 77-day-old rats evoked adipocyte hyperplasia and fat mass gain without inflammation, unlike in 49- to 56-day-old rats.