Key result
LVEF ≤35% before 34 weeks gestation linked to postpartum heart failure in dilated cardiomyopathy.
Why the study?
Emergency cesarean delivery in heart failure increases maternal and fetal mortality, but the relationship between anesthesia for delivery, cardiac deterioration, and outcomes in dilated cardiomyopathy requires evaluation.
Does the type of anesthesia during delivery affect the risk of progressive cardiac deterioration in pregnant women with dilated cardiomyopathy?
Cohort (n=29)
No
Does the type of anesthesia during delivery affect the risk of progressive cardiac deterioration in pregnant women with dilated cardiomyopathy?
A preterm anesthetic evaluation is warranted to optimize management for pregnant women with dilated cardiomyopathy when their ejection fraction decreases to ≤ 35% before 34 weeks gestation.
LVEF ≤35% before 34 weeks may flag elevated peripartum heart failure risk in dilated cardiomyopathy; leaves open whether anesthesia type modifies outcomes.
Emergency cesarean delivery in patients with heart failure increases maternal and fetal mortality. The present study aimed to identify the relationship between the use of anesthesia for delivery and progressive cardiac deterioration in women with dilated cardiomyopathy (DCM) and to examine its implications on maternal and fetal outcomes. Twenty-nine pregnancies in 25 women with DCM from the National Cerebral and Cardiovascular Center Hospital (Suita, Japan) were included in this retrospective longitudinal study. Fourteen of the patients (48.3%) delivered via cesarean section. Among these, 4 patients (13.8%) experienced heart failure within 42 days of delivery. The indication for cesarean delivery was heart failure in 3 patients and induction failure in 1 patient. The types of anesthesia used for these patients included general (n = 1), combined spinal-epidural (n = 2), and epidural (n = 1). Two of these cesarean deliveries were performed preterm. The left ventricular ejection fraction of patients with heart failure was ≤ 35% before 34 weeks gestation. Among the 25 patients without heart failure, 2 exhibited a left ventricular ejection fraction of ≤ 35% before 34 weeks gestation. Meanwhile, the types of anesthesia used for remaining 10 patients who did not experience heart failure included general (n = 1), combined spinal-epidural (n = 8), and epidural (n = 1). The rate of general anesthesia was 25% in patients who experienced heart failure and 4% in others. There was no incidence of maternal or fetal death. A preterm anesthetic evaluation may be warranted to optimize anesthetic management when the ejection fraction decreases to ≤ 35% before 34 weeks gestation in patients with DCM.
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Sasaki et al. (2023) conducted a cohort in Dilated cardiomyopathy in pregnancy (n=29). Anesthesia during delivery (general, combined spinal-epidural, or epidural) was evaluated on Incidence of heart failure within 42 days of delivery. Among pregnant women with dilated cardiomyopathy, a left ventricular ejection fraction ≤35% before 34 weeks gestation was associated with heart failure within 42 days of delivery.
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