Key result
Transplantation of human adipose tissue-derived multilineage progenitor cells significantly reduced total cholesterol and increased LDL clearance in a rabbit model of familial hypercholesterolemia.
Why the study?
Does transplantation of human adipose tissue-derived multilineage progenitor cells reduce serum cholesterol in Watanabe heritable hyperlipidemic rabbits?
Population
Watanabe heritable hyperlipidemic rabbits, an animal model for homozygous familial hypercholesterolemia
Comparison
Transplantation of human adipose tissue-derived… vs WHHL rabbits without transplanted hADMPCs
Design
Preclinical
Follow-up
12 weeks
Authors
Loading...
Hypothesis-generating for cell therapy in homozygous FH; human trials required before clinical consideration.
Does transplantation of human adipose tissue-derived multilineage progenitor cells reduce serum cholesterol in Watanabe heritable hyperlipidemic rabbits?
Transplantation of human adipose tissue-derived multilineage progenitor cells significantly reduces total cholesterol and improves LDL clearance in an animal model of homozygous familial hypercholesterolemia.
Okura et al. (2010) studied Familial hypercholesterolemia. Human adipose tissue-derived multilineage progenitor cells (hADMPCs) vs. No transplantation was evaluated on Total cholesterol and LDL clearance. Transplantation of human adipose tissue-derived multilineage progenitor cells significantly reduced total cholesterol and increased LDL clearance in a rabbit model of familial hypercholesterolemia.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: