Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1977Journal of General Virology

Immunogenic and Cell Attachment Sites of FMDV: Further Evidence for their Location in a Single Capsid Polypeptide

View Full Paper
Ask AI
Bookmark
Share

Population

Foot-and-mouth disease virus (FMDV serotype O) and strains from five other serotypes; BHK 21 cells

Comparison

Enzymatic cleavage by chymotrypsin and trypsin vs Intact virus and different stages of hydrolysis

Design

Preclinical

Authors

DCD. CavanaghCentre for Immunity, Infection and EvolutionDSD. V. SangarUniversity of North Carolina at Chapel HillDRDavid J. RowlandsUniversity of Leeds

Discussion

Loading...

Member takes

Overview

Supports VP1 localization of FMDV sites; extends epitope mapping but leaves open vaccine translation from animal data.

Structured PICO

P
Population
Foot-and-mouth disease virus (FMDV serotype O) and strains from five other serotypes; BHK 21 cells
I
Intervention
Enzymatic cleavage by chymotrypsin and trypsin
C
Comparator
Intact virus and different stages of hydrolysis
O
Outcome
Infectivity, rate of attachment to BHK 21 cells, and immunogenic activitysurrogate

The study provides evidence that the immunogenic and cell attachment sites of FMDV are located on a single capsid polypeptide (VP1).

Cite This Study

Cavanagh et al. (1977) studied this question.

synapsesocial.com/papers/6a6f5643ac440176ef280786https://doi.org/10.1099/0022-1317-35-1-149
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of the Minor Polypeptides in the Foot-and-Mouth Disease Particle1976 · 32 citations
  2. 2Evidence for a Group Protein in Foot-and-Mouth Disease Virus Particles1973 · 44 citations
  3. 3Structural Proteins of Foot-and-Mouth Disease Virus1973 · 23 citations
  4. 4Relationship of the Antigenic Structure of Foot-and-Mouth Disease Virus to the Process of Infection1971 · 48 citations
  5. 5Surface Structure of Foot-and-Mouth Disease Virus1969 · 117 citations