Key result
Laboratory animal models, particularly mice and guinea pigs, have provided valuable insights into foot-and-mouth disease virus pathogenesis and immune responses despite differences from natural hosts.
Laboratory animal models, particularly mice, offer a versatile and cost-effective system to study FMDV pathogenesis and evaluate vaccines before testing in natural hosts.
Rodent models may accelerate early FMDV research; leaves open translation to natural hosts without further validation.
Laboratory animal models have provided valuable insight into foot-and-mouth disease virus (FMDV) pathogenesis in epidemiologically important target species. While not perfect, these models have delivered an accelerated time frame to characterize the immune responses in natural hosts and a platform to evaluate therapeutics and vaccine candidates at a reduced cost. Further expansion of these models in mice has allowed access to genetic mutations not available for target species, providing a powerful and versatile experimental system to interrogate the immune response to FMDV and to target more expensive studies in natural hosts. The purpose of this review is to describe commonly used FMDV infection models in laboratory animals and to cite examples of when these models have failed or successfully provided insight relevant for target species, with an emphasis on natural and vaccine-induced immunity.
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Habiela et al. (2014) conducted a review in Foot-and-mouth disease. Laboratory animal models was evaluated. Laboratory animal models, particularly mice and guinea pigs, have provided valuable insights into foot-and-mouth disease virus pathogenesis and immune responses despite differences from natural hosts.
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