Key result
Novel recombinant enterovirus G isolates carrying a torovirus papain-like cysteine protease gene were detected in 10.3% of diarrheic samples from weaned piglets in Jeju Province, South Korea.
Why the study?
Enterovirus species G is highly diverse and ubiquitous in pig populations, but the presence of novel EV-G recombinants with torovirus papain-like cysteine protease in Jeju pig herds required investigation.
Cross-Sectional (n=107)
Yes
EV-G1-PLCP may contribute to weaned-piglet diarrhea; leaves open recombinant enterovirus pathogenicity in swine.
Enterovirus species G (EV-G) is highly diverse, and is ubiquitous in pig populations, usually without diarrhea. The present study aimed to investigate the presence of novel EV-G recombinants with the torovirus papain-like cysteine protease (PLCP) in Jeju pig herds. EV-G1-PLCP mono-infections were most prevalent in diarrheic weaned piglets. The PLCP genes of the Jeju isolates varied in size and junction sequences, and were greatly heterogeneous, with 77.0-90.7% homology amongst all recombinants. Our results suggest that the exogenous PLCP gene has undergone continuous rapid mutation in the individual EV-G genomes following crossorder recombination, thereby causing clinical disease in swine.
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Jeon et al. (2019) conducted a cross-sectional in Porcine diarrhea (n=107). EV-G-PLCP infection was evaluated on Prevalence of EV-G-PLCP in diarrheic samples. Novel recombinant enterovirus G isolates carrying a torovirus papain-like cysteine protease gene were detected in 10.3% of diarrheic samples from weaned piglets in Jeju Province, South Korea.
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