Key result
Understanding the variances in virulence and immune responses among FMD-susceptible host species serves as an important foundation for the rational design of vaccines and countermeasure strategies.
Why the study?
Improving current vaccine platforms could help control foot-and-mouth disease outbreaks and support disease eradication, requiring a bridged understanding between virus biology and practical control strategies.
This review summarizes host-pathogen interactions in foot-and-mouth disease to inform rational vaccine design and countermeasure strategies in livestock.
Species differences in FMD immunity may require tailored vaccines; leaves open optimized platforms for bovines versus pigs.
Foot-and-mouth disease (FMD) is globally recognized as a highly economically devastating and prioritized viral disease affecting livestock. Vaccination remains a crucial preventive measure against FMD. The improvement of current vaccine platforms could help control outbreaks, leading to the potential eradication of the disease. In this review, we describe the variances in virulence and immune responses among FMD-susceptible host species, specifically bovines and pigs, highlighting the details of host-pathogen interactions and their impact on the severity of the disease. This knowledge serves as an important foundation for translating our insights into the rational design of vaccines and countermeasure strategies, including the use of interferon as a biotherapeutic agent. Ultimately, in this review, we aim to bridge the gap between our understanding of FMDV biology and the practical approaches to control and potentially eradicate FMD.
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Medina et al. (2024) conducted a review in Foot-and-mouth disease (FMD). Understanding the variances in virulence and immune responses among FMD-susceptible host species serves as an important foundation for the rational design of vaccines and countermeasure strategies.
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