Key result
Foot-and-mouth disease virus employs complex immune evasion strategies, such as antigenic variation and subversion of innate and adaptive responses, posing significant challenges for vaccine development.
Why the study?
Foot-and-mouth disease virus causes devastating disease in cloven-hoofed animals worldwide by evolving complex strategies to evade immune recognition and elimination.
Understanding the complex immune evasion mechanisms of FMDV is critical for overcoming current challenges in developing effective, broad-spectrum vaccines and therapeutics for this economically devastating animal disease.
FMDV immune evasion mechanisms may guide vaccine strategies; leaves open targeted interventions in livestock.
Foot-and-mouth disease virus (FMDV) is a highly contagious and economically devastating pathogen that affects cloven-hoofed animals worldwide. FMDV infection causes vesicular lesions in the mouth, feet, and mammary glands, as well as severe systemic symptoms such as fever, salivation, and lameness. The pathogenesis of FMDV infection involves complex interactions between the virus and the host immune system, which determine the outcome of the disease. FMDV has evolved several strategies to evade immune recognition and elimination, such as antigenic variation, receptor switching, immune suppression, and subversion of innate and adaptive responses. This review paper summarizes the current knowledge on the pathogenesis of FMDV infection and the mechanisms of immune evasion employed by the virus. It also discusses the challenges and opportunities for developing effective vaccines and therapeutics against this important animal disease.
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Kabir et al. (2024) conducted a review in Foot-and-mouth disease virus (FMDV) infection. Foot-and-mouth disease virus (FMDV) was evaluated. Foot-and-mouth disease virus employs complex immune evasion strategies, such as antigenic variation and subversion of innate and adaptive responses, posing significant challenges for vaccine development.
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