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June 1, 2016Transboundary and Emerging Diseases

Global Foot-and-Mouth Disease Research Update and Gap Analysis: 7 - Pathogenesis and Molecular Biology

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Key result

A literature review of FMDV pathogenesis and molecular biology from 33 global institutes identified key advances in virus retention, cellular entry, and immune evasion to guide future research.

Population

Foot-and-mouth disease virus (FMDV) research literature (2011-2015) and updates from 33 institutes worldwide

Design

Review

Authors

LRLucy RobinsonWelsh GovernmentTKThéodore Knight-JonesInternational Livestock Research InstituteBCBryan CharlestonUniversity of Nebraska–Lincoln

Discussion

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Implication

Synthesizes FMDV molecular advances; leaves open experimental validation for vaccines or control strategies.

Key Points

  • Assess global research progress and critical knowledge gaps regarding foot-and-mouth disease virus pathogenesis and molecular biology to guide future disease control strategies.
  • Synthesized peer-reviewed literature published globally between 2011 and 2015.
  • Collected and analyzed research updates in 2014 from 33 specialist research institutes across the world.
  • FMDV persists in the lymph nodes of recovered animals across multiple species, with viral entry and tissue tropism dictated by integrin expression, cellular clearance rates, and type I interferon responses.
  • Identified viral exploitation of autophagosomes for cytoplasmic entry and specific viral proteins that evade immunity by suppressing type I interferon production, informing targets for antiviral therapies and capsid-stable vaccines.

Structured PICO

P
Population
Foot-and-mouth disease virus (FMDV) research literature (2011-2015) and updates from 33 institutes worldwide

This review highlights recent advances and knowledge gaps in FMDV pathogenesis and molecular biology to direct future research for improved disease control.

Limitations

  • Extending findings to improved understanding of transmission requires a standardized approach and adoption of natural routes of infection during experimental study.

Cite This Study

Robinson et al. (2016) conducted a review in Foot-and-Mouth Disease. A literature review of FMDV pathogenesis and molecular biology from 33 global institutes identified key advances in virus retention, cellular entry, and immune evasion to guide future research.

synapsesocial.com/papers/6a6f5703f44fa9f079dcc39chttps://doi.org/10.1111/tbed.12520
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Also Consider

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