Key result
FMD vaccine formulated based on antigenic mass (≥1.5 μg/2ml for small ruminants) provided a protective immune response of better quality and potency than volume-based formulation.
Why the study?
Does formulating FMD vaccine based on antigenic mass improve protective immune response in vaccinated sheep compared to volume-based formulation?
Does formulating FMD vaccine based on antigenic mass improve protective immune response in vaccinated sheep compared to volume-based formulation?
Formulating FMD vaccines based on quantified 146S antigenic mass rather than suspension volume improves vaccine quality and potency in sheep.
Antigenic mass-based FMD formulation may improve potency in small ruminants; leaves open field validation before wider use.
The antigen mass load of foot-and-mouth disease virus (FMDV) is one of the critical clues to produce apotent vaccine. In the current work, the quantification of the virus 146S antigen content was describedand the relationship between antigen mass in the vaccine and the immune response to FMDV invaccinated sheep were investigated. It was found that FMD vaccine containing at least 1.5 μg/2ml (smallruminant dose) or 3 μg/2ml (cattle and buffaloes dose) from each serotype of FMDV 146S particles andvirus titers 6.55-7.3 log10 TCID50/ml gave protective immune response against FMDV. Moreover,relying on the antigenic mass coupled to ultrafiltration of the virus was showed to be of better qualityand potency than depending on the volume of the virus suspensions in the formulation of FMD vaccine;however, the former technology needs with standing more cost and effort
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Abu-Elnaga et al. (2015) studied Foot-and-mouth disease. FMD vaccine based on antigenic mass vs. FMD vaccine based on volume of virus suspensions was evaluated on Protective immune response against FMDV. FMD vaccine formulated based on antigenic mass (≥1.5 μg/2ml for small ruminants) provided a protective immune response of better quality and potency than volume-based formulation.
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