Key result
Cognitive reserve proxies such as education, premorbid IQ, occupational complexity, and lifetime cognitive activity exhibited distinct moderating effects on the relationship between AD pathologies and cognition.
Why the study?
To explore the moderating effects of frequently used cognitive reserve proxies on the relationships between various in vivo Alzheimer disease pathologies and cognition.
Do cognitive reserve proxies moderate the relationship between Alzheimer's disease pathologies and cognition in older adults?
Population
351 older adults (268 cognitively unimpaired, 83 cognitive impaired)
Comparison
Effects across cognitive reserve proxies (education, pIQ, OC, LCA)
Design
Observational study
Authors
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CR proxies may moderate AD pathology-cognition links; leaves open their causal impact and need for longitudinal validation before clinical use.
Observational (n=351)
Do cognitive reserve proxies moderate the relationship between Alzheimer's disease pathologies and cognition in older adults?
Different cognitive reserve proxies have distinct moderating effects on the relationships between specific Alzheimer's disease pathologies and cognition, particularly in cognitively impaired individuals.
Ko et al. (2021) conducted an observational in Alzheimer's disease pathologies and cognition (n=351). Cognitive reserve proxies (education, premorbid intelligence quotient, occupational complexity, and lifetime cognitive activity) was evaluated on Moderating effects on the relationship between various in vivo Alzheimer's disease pathologies and cognition. Cognitive reserve proxies such as education, premorbid IQ, occupational complexity, and lifetime cognitive activity exhibited distinct moderating effects on the relationship between AD pathologies and cognition.
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